| Date | Location | Result | |
| 03/03/22 | Cleveland, Ohio / Wolstein Center | Cleveland State 83, RMU 67 | Box score |
| 03/01/22 | Youngstown, Ohio / Beeghly Center | RMU 77, Youngstown State 73 | Box score |
| 02/26/22 | Fairborn, Ohio / Nutter Center | Wright State 71, RMU 61 | Box score |
| 02/24/22 | Highland Heights, Ky. / BB&T Arena | Northern Kentucky 78, RMU 64 | Box score |
| 02/19/22 | Moon Township, Pa. / UPMC Events Center | UIC 96, RMU 88 (OT) | Box score |
| 02/17/22 | Moon Township, Pa. / UPMC Events Center | IUPUI 66, RMU 56 | Box score |
| 02/13/22 | Youngstown, Ohio / Beeghly Center | RMU 73, Youngstown State 68 | Box score |
| 02/11/22 | Moon Township, Pa. / UPMC Events Center | Oakland 71, RMU 68 | Box score |
| 02/09/22 | Moon Township, Pa. / UPMC Events Center | Detroit Mercy 79, RMU 62 | Box score |
| 02/05/22 | Indianapolis, Ind. / Farmers Coliseum | RMU 66, IUPUI 49 | Box score |
| 02/03/22 | Chicago, Ill. / Credit Union 1 Arena | UIC 80, RMU 75 | Box score |
| 01/29/22 | Moon Township, Pa. / UPMC Events Center | RMU 62, Green Bay 60 | Box score |
| 01/27/22 | Moon Township, Pa. / UPMC Events Center | RMU 77, Milwaukee 53 | Box score |
| 01/23/22 | Cleveland, Ohio / Wolstein Center | Cleveland State 75, RMU 68 | Box score |
| 01/21/22 | Fort Wayne, Ind. / Memorial Coliseum | Purdue Fort Wayne 86, RMU 62 | Box score |
| 01/15/22 | Moon Township, Pa. / UPMC Events Center | RMU 74, Northern Kentucky 64 | Box score |
| 01/13/22 | Moon Township, Pa. / UPMC Events Center | Wright State 75, RMU 73 | Box score |
| 01/09/22 | Moon Township, Pa. / UPMC Events Center | Purdue Fort Wayne 76, RMU 70 | Box score |
| 01/07/22 | Moon Township, Pa. / UPMC Events Center | Cleveland State 78, RMU 77 | Box score |
| 01/05/22 | Moon Township, Pa. / UPMC Events Center | Youngstown State 64, RMU 60 | Box score |
| 12/30/21 | Rochester, Mich. / Ath. Center O'Rena | Oakland 79, RMU 61 | Box score |
| 12/22/21 | Loretto, Pa. / DeGol Arena | RMU 75, Saint Francis U 67 | Box score |
| 12/19/21 | Bowling Green, Ohio / Stroh Center | Bowling Green 100, RMU 74 | Box score |
| 12/11/21 | Moon Township, Pa. / UPMC Events Center | FGCU 85, RMU 74 | Box score |
| 12/08/21 | Moon Township, Pa. / UPMC Events Center | RMU 99, Lancaster Bible 51 | Box score |
| 12/04/21 | Milwaukee, Wisc. / UWM Panther Arena | Milwaukee 77, RMU 69 | Box score |
| 12/02/21 | Green Bay, Wisc. / Resch Center | Green Bay 70, RMU 58 | Box score |
| 11/27/21 | Davidson, N.C. / John M. Belk Arena | Davidson 88, RMU 70 | Box score |
| 11/19/21 | Moon Township, Pa. / UPMC Events Center | Mount St. Mary's 74, RMU 70 (OT) | Box score |
| 11/15/21 | Athens, Ohio / Convocation Center | Ohio 85, RMU 71 | Box score |
| 11/12/21 | Lexington, Ky. / Rupp Arena | Kentucky 100, RMU 60 | Box score |
| 11/10/21 | Orlando, Fla. / Addition Financial Arena | UCF 69, RMU 59 | Box score |